Two quantitative models for the effect of high total macromolecular volume occupancy (‘macromolecular crowding’) upon the chemical inhibition of protein fibrillation are presented. The first assumes that fibrillation is reversible, and the second assumes that fibrillation is irreversible. Both models predict that small molecule inhibitors will be less effective in crowded media than in dilute media, whereas macromolecular inhibitors are likely to retain their efficiency in crowded media. It is suggested that the coupling of one or more small-molecule inhibitors to an “inert” macromolecular support will increase inhibition efficiency in crowded media.

中文翻译：

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排除体积对化学抑制蛋白原纤维形成的影响。

提出了两个定量模型，这些模型对蛋白原纤化的化学抑制作用具有较高的总大分子体积占有率（“大分子拥挤”）。第一个假设原纤维形成是可逆的，第二个假设原纤维形成是不可逆的。两种模型都预测，小分子抑制剂在拥挤培养基中的效力要比在稀释培养基中低，而大分子抑制剂则可能在拥挤培养基中保持其效力。建议将一种或多种小分子抑制剂与“惰性”大分子载体偶联将增加在拥挤培养基中的抑制效率。