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In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes
Journal of Polymers and the Environment ( IF 5.3 ) Pub Date : 2020-06-26 , DOI: 10.1007/s10924-020-01803-x
Alexander G. Morozov , Danila A. Razborov , Tatevik A. Egiazaryan , Maxim A. Baten’kin , Diana Ya. Aleynik , Marfa N. Egorikhina , Yulia P. Rubtsova , Irina N. Charikova , Sergei A. Chesnokov , Igor L. Fedushkin

An atactic poly-d,l-lactide (PLA) is obtained via ring-opening polymerization (ROP) of lactide stereoisomers mixture catalyzed by the magnesium and calcium acenaphthylenebisamido complexes. The polymer is characterized by gel-permeation chromatography, NMR spectroscopy, and mass spectrometry. The hydrolytic degradation behavior, cytotoxicity, and cell adhesion of the resulting PLA are evaluated. The polymer degrades in phosphate-buffered saline, releasing water-soluble low molecular products that significantly influence dermal fibroblast growth. Polymer demonstrates no cytotoxicity that, along with cell adhesion and their high proliferative activity toward the PLA obtained, proves its biocompatibility.



中文翻译:

用于生物医学目的的无规聚乳酸的降解行为,细胞毒性和细胞粘附性的体外研究

无规立构聚d-丙交酯(PLA)经由由镁和钙acenaphthylenebisamido络合物催化的丙交酯的立体异构体混合物的开环聚合(ROP)获得。该聚合物通过凝胶渗透色谱法,NMR光谱法和质谱法表征。评价所得PLA的水解降解行为,细胞毒性和细胞粘附性。该聚合物在磷酸盐缓冲盐水中降解,释放出水溶性低分子产物,该产物显着影响真皮成纤维细胞的生长。聚合物没有显示出细胞毒性,与细胞粘附以及它们对PLA的高增殖活性无关,也没有证明其具有生物相容性。

更新日期:2020-08-27
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