In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans. Scans of twenty patients were analyzed in this study. Patients were injected with 68Ga-PSMA-11 (mean, 5.50 ± 1.49 mCi) and imaged on a 3.0 T time-of-flight PET/MRI. PET images were retrospectively reconstructed using 0.5, 1, 2, 4, 7, and 10 min of PET data. Lesion detectability was evaluated on a 5-point Likert Scale for each lesion in each reconstruction. Quantitative analysis was performed measuring image noise and lesion uptake. A total of 55 lesions were identified, and lesion detectability increased from 2.07 ± 1.14 for 0.5 min to 4.93 ± 0.26 for 10 min (p < 0.001), with no significant difference detected between 7 and 10 min of scan time. Average SUVmax decreased from 9.89 ± 6.62 for 0.5 min to 8.64 ± 6.81 for 10 min. Noise decreased from 0.72 ± 0.22 for 0.5 min to 0.31 ± 0.12 for 10 min (p < 0.001) and were nearly equivalent between 7 and 10 min. Pairwise interaction terms between size, SUVmax, and scan time were all found to be significant, although the interaction term between SUVmax and scan time was found to be the most significant. Increased acquisition duration improves image quality by increasing detectability and reducing noise. In patients with biochemical recurrence, increased acquisition time up to 7 min improves lesion detection.

中文翻译：

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68Ga-PSMA-11 PET / MRI：确定理想的采集时间以减少噪声并提高图像质量。

在这项研究中，我们调查了68Ga-PSMA-11 PET / MRI扫描中每张床位PET采集时间增加对病变可检测性，标准摄取值和图像噪声的影响。在这项研究中分析了二十名患者的扫描。患者被注射68Ga-PSMA-11（平均5.50±1.49 mCi），并在3.0 T飞行时间PET / MRI上成像。使用0.5、1、2、4、7和10分钟的PET数据回顾性重建PET图像。在每个重建过程中，针对每个病变的5点Likert量表评估了病变的可检测性。进行定量分析以测量图像噪声和病灶摄取。总共鉴定出55个病灶，病灶的可检测性从0.5分钟的2.07±1.14增加到10分钟的4.93±0.26（p <0.001），而在7到10分钟的扫描时间内未发现明显差异。平均SUVmax从0.5分钟的9.89±6.62降至10分钟的8.64±6.81。噪音从0.5分钟的0.72±0.22降低到10分钟的0.31±0.12（p <0.001），在7至10分钟之间几乎相等。大小，SUVmax和扫描时间之间的成对交互项都被认为是重要的，尽管SUVmax与扫描时间之间的交互项是最重要的。增加的采集持续时间通过提高可检测性和减少噪声来改善图像质量。在生化复发患者中，增加采集时间长达7分钟可改善病变检测。尽管发现SUVmax与扫描时间之间的交互项最为重要，但SUVmax和扫描时间都被认为是重要的。增加的采集持续时间通过提高可检测性和减少噪声来改善图像质量。在生化复发患者中，增加采集时间长达7分钟可改善病变检测。尽管发现SUVmax与扫描时间之间的交互项最为重要，但SUVmax和扫描时间都被认为是重要的。增加的采集持续时间通过提高可检测性和减少噪声来改善图像质量。对于具有生化复发的患者，增加长达7分钟的采集时间可改善病变检测。