Dietary macronutrients may indirectly affect body weight through their interactions with the fat mass and obesity associated (FTO) gene. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macronutrients intake in overweight adults. This study was carried out on 196 overweight adults of Shiraz, Iran. Dietary intake was assessed using a validated 168-item semi-quantitative food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. The association between dietary macronutrients and the FTO genotype were assessed using linear regression after adjustments for sex, age, physical activity, and the serum levels of triglycerides, fasting blood sugar (FBS), and low density lipoprotein (LDL). The higher intake of carbohydrates (P < 0.001), fat (P = 0.009), and calorie (P = 0.001) were significantly associated with rs9939609 AA genotype (P = 0.001). Carriers of the AA genotype of rs9939609 had significantly higher calorie, fat, and carbohydrate intake than the carriers of the TT genotype after adjusting for age and sex (P = 0.019, P = 0.010 and P = 0.001, respectively). Further adjustments for physical activity, TG, LDL, and FBS did not change these results. The amounts of dietary calorie, carbohydrate, and fat intake were associated with FTO genotype. Further studies are warranted to confirm these associations and to identify the underlying mechanisms.

中文翻译：

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超重成年人中FTO基因型与大量营养素和卡路里摄入之间的关联。

饮食中的大量营养素可能通过与脂肪和肥胖相关基因（FTO）的相互作用而间接影响体重。这项研究旨在调查超重成年人FTO基因rs9939609多态性与大量营养摄入之间的关系。这项研究是针对伊朗设拉子的196名超重成年人进行的。使用经过验证的168项半定量食物频率调查表（FFQ）评估饮食摄入量。FTO基因的rs9939609多态性的基因型。在调整性别，年龄，身体活动以及血清甘油三酸酯，空腹血糖（FBS）和低密度脂蛋白（LDL）的水平后，使用线性回归评估饮食中大量营养素与FTO基因型之间的关联。碳水化合物（P <0.001），脂肪（P = 0.009）和卡路里（P = 0）的摄入量较高。001）与rs9939609 AA基因型显着相关（P = 0.001）。调整年龄和性别后，rs9939609的AA基因型携带者的卡路里，脂肪和碳水化合物摄入量显着高于TT基因型的携带者（分别为P = 0.019，P = 0.010和P = 0.001）。对身体活动，TG，LDL和FBS的进一步调整并没有改变这些结果。饮食中的卡路里，碳水化合物和脂肪摄入量与FTO基因型相关。有必要进行进一步的研究以确认这些关联并确定潜在的机制。001）。对身体活动，TG，LDL和FBS的进一步调整并没有改变这些结果。饮食中的卡路里，碳水化合物和脂肪摄入量与FTO基因型相关。有必要进行进一步的研究以确认这些关联并确定潜在的机制。001）。对身体活动，TG，LDL和FBS的进一步调整并没有改变这些结果。饮食中的卡路里，碳水化合物和脂肪摄入量与FTO基因型相关。有必要进行进一步的研究以确认这些关联并确定潜在的机制。