Herein, we report a nickel-catalyzed reductive cross-coupling reaction of easily accessible 3-butenyl carbamoyl chloride with primary alkyl iodide to access the chiral α-alkylated pyrrolidinone with broad substrate scope and high ee. The current art of synthesis still remains challenging on the enantioselective α-monoalkylation of pyrrolidinones. The newly designed chiral 8-quinoline imidazoline ligand (Quinim) is crucial for maintaining the reactivity and enantioselectivity to ensure the reductive cyclization of mono-substituted alkenes for unprecedented synthesis of chiral nonaromatic heterocycles.

中文翻译：

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Quinim：一种新的配体支架，使镍催化对映选择性合成 α-烷基化 γ-内酰胺

在此，我们报告了镍催化的 3-丁烯基氨基甲酰氯与伯烷基碘的还原交叉偶联反应，以获得具有广泛底物范围和高 ee 的手性 α-烷基化吡咯烷酮。目前的合成技术对吡咯烷酮的对映选择性 α-单烷基化仍然具有挑战性。新设计的手性 8-喹啉咪唑啉配体（Quinim）对于保持反应性和对映选择性至关重要，以确保单取代烯烃的还原环化，从而前所未有地合成手性非芳香杂环。