Poly(ethylene glycols) (PEGs) are extensively explored by the pharma industry as foundations for new therapeutic products. PEGs are typically used for their conjugation to active drugs, peptides, and proteins and the likeliness to increase the half-life and enhance the therapeutic outcome. Considering the necessity of batch-to-batch consistency for clinical products, monodisperse PEGs are highly attractive but are generally limited to 5 kDa as an upper molecular weight (M_w) and with an oligomer purity of 95%. By amalgamating short, monodisperse PEGs with dendritic frameworks based on 2,2-bis(methylol)propionic acid polyesters, we showcase a robust synthetic approach to monodisperse PEGs with M_w ranging from 2 to 65 kDa. The latter is, to our knowledge, the highest M_w structure of its kind ever reported. Importantly, the dendritic multifunctional connector facilitated degradability at pH 7.4 at 37 °C, which is an important feature for the delivery of therapeutic agents.

中文翻译：

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可降解的高分子量单分散树枝状聚乙二醇。

医药行业广泛地探索聚乙二醇（PEG）作为新治疗产品的基础。PEG通常用于与活性药物，肽和蛋白质等结合，以增加半衰期并增强治疗效果。考虑到临床产品批次间一致性的必要性，单分散PEG具有很高的吸引力，但其上限分子量（M _w）通常限制为5 kDa，低聚物纯度为95％。通过将短的单分散PEG与基于2,2-双（羟甲基）丙酸聚酯的树枝状骨架合并，我们展示了一种稳健的合成方法，可将M _w单分散PEG范围从2到65 kDa。后者则是，据我们所知，最高的中号_W¯¯同类结构不断报道。重要的是，树状多功能连接器促进了pH 7.4在37°C下的降解，这是治疗剂传递的重要特征。