A bio-inspired nanodevice for the selective and sensitive fluorogenic detection of 3,4-methylenedioxypyrovalerone (MDPV), usually known as Cannibal drug, is reported. The sensing nanodevice is based on mesoporous silica nanoparticles (MSNs), loaded with a fluorescent reporter (rhodamine B), and functionalized on their external surface with a dopamine derivative (3), which specifically interacts with the recombinant human dopamine transporter (DAT), capping the pores. In the presence of MDPV, DAT detaches from the MSNs consequently, causing rhodamine B release and allowing drug detection. The nanosensor shows a detection limit of 5.2 μM, and it is able to detect the MDPV drug both in saliva and blood plasma samples.

中文翻译：

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用于食人药原位检测的灵敏纳米传感器。

据报道，一种生物启发性的纳米装置可选择性和灵敏地检测3,4-亚甲二氧基吡咯烷酮（MDPV），通常被称为食人药。感测纳米器件基于中孔二氧化硅纳米颗粒（MSN），该纳米颗粒装有荧光报告分子（罗丹明B），并在其外表面用多巴胺衍生物（3）进行功能化，该多巴胺衍生物与重组人多巴胺转运蛋白（DAT）特异性相互作用，遮盖毛孔。因此，在MDPV的存在下，DAT从MSN脱离，导致罗丹明B释放并允许进行药物检测。纳米传感器的检测极限为5.2μM，能够检测唾液和血浆样品中的MDPV药物。