Hi-C experiments couple DNA-DNA proximity with next-generation sequencing to yield an unbiased description of genome-wide interactions. Previous methods describing Hi-C experiments have focused on the industry-standard Illumina sequencing. With new next-generation sequencing platforms such as BGISEQ-500 becoming more widely available, protocol adaptations to fit platform-specific requirements are useful to give increased choice to researchers who routinely generate sequencing data.

中文翻译：

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使用 BGISEQ-500 平台对鸟类基因组进行 Hi-C 染色体构象捕获测序。

Hi-C 实验将 DNA-DNA 邻近性与下一代测序结合起来，以产生对全基因组相互作用的公正描述。以前描述 Hi-C 实验的方法主要集中于行业标准 Illumina 测序。随着 BGISEQ-500 等新的下一代测序平台变得越来越广泛，适应平台特定要求的协议调整有助于为定期生成测序数据的研究人员提供更多选择。