Coxsackievirus A24 variant (CVA24v) and human adenovirus 37 (HAdV-37) are leading causative agents of the severe and highly contagious ocular infections acute hemorrhagic conjunctivitis and epidemic keratoconjunctivitis, respectively. Currently, neither vaccines nor antiviral agents are available for treating these diseases, which affect millions of individuals worldwide. CVA24v and HAdV-37 utilize sialic acid as attachment receptors facilitating entry into host cells. Previously, we and others have shown that derivatives based on sialic acid are effective in preventing HAdV-37 binding and infection of cells. Here, we designed and synthesized novel pentavalent sialic acid conjugates and studied their inhibitory effect against CVA24v and HAdV-37 binding and infection of human corneal epithelial cells. The pentavalent conjugates are the first reported inhibitors of CVA24v infection and proved efficient in blocking HAdV-37 binding. Taken together, the pentavalent conjugates presented here form a basis for the development of general inhibitors of these highly contagious ocular pathogens.

中文翻译：

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五价唾液酸结合了可引起高度传染性眼部感染的块状柯萨奇病毒A24变异株和人腺病毒37型病毒。

柯萨奇病毒A24变体（CVA24v）和人腺病毒37（HAdV-37）分别是严重和高度传染性眼部感染，急性出血性结膜炎和流行性角膜结膜炎的主要病原体。目前，尚无疫苗和抗病毒剂可用于治疗这些疾病，这些疾病影响着全球数百万的人。CVA24v和HAdV-37利用唾液酸作为附着受体，有助于进入宿主细胞。以前，我们和其他人已经表明，基于唾液酸的衍生物可有效预防HAdV-37结合和细胞感染。在这里，我们设计和合成了新型五价唾液酸缀合物，并研究了它们对CVA24v和HAdV-37结合以及人角膜上皮细胞感染的抑制作用。五价缀合物是最早报道的CVA24v感染抑制剂，并被证明可有效阻断HAdV-37的结合。综上所述，此处介绍的五价缀合物构成了开发这些高度传染性眼病原体的一般抑制剂的基础。