ABSTRACT

Introduction

Unregulated e-cigarette devices and their nicotine content have amplified the potential of e-cigarettes as addictive agents. Several e-cigarette-related parameters have been identified altering nicotine’s absorption profile, so their potential effects on addiction should be considered. Of these factors, nicotine forms (protonated and free base) play a significant role in the addiction potential yet their impact on nicotine’s absorption has been studied with limited research.

Areas covered

Current review aims to emphasize on the possible mechanism behind different absorption profiles of nicotine forms considering their physical states (droplet and vapor phase) and the aerosol particle size, their analysis in e-cigarette research and the regulatory attention warranted by them to combat nicotine addiction in the population due to e-cigarettes.

Expert opinion

The protonated form of nicotine is being correlated with the smooth sensory effects and high nicotine absorption as compared to free base nicotine. With the introduction of nicotine salts, which yield mostly the protonated form, the youth popularity of e-cigarettes has spiked exponentially. While it is important to control nicotine levels in e-cigarette products, attention should also be given to the nicotine forms present in these products in order to address nicotine addiction in the population.

中文翻译：

---

尼古丁形式：它们为什么以及如何影响电子香烟的尼古丁输送？

摘要

介绍

不受管制的电子烟设备及其尼古丁含量放大了电子烟作为成瘾剂的潜力。已经确定了几个与电子烟相关的参数会改变尼古丁的吸收曲线，因此应考虑它们对成瘾的潜在影响。在这些因素中，尼古丁形式（质子化和游离碱）在成瘾潜力中起重要作用，但它们对尼古丁吸收的影响已被有限的研究研究。

涵盖的领域

目前的审查旨在强调尼古丁形式的不同吸收曲线背后的可能机制，考虑到它们的物理状态（液滴和蒸气相）和气溶胶颗粒大小，它们在电子烟研究中的分析以及它们为打击尼古丁成瘾而应引起的监管关注由于电子烟而在人口中。

专家意见

与游离碱尼古丁相比，质子化形式的尼古丁与平滑的感官效果和高尼古丁吸收有关。随着主要产生质子形式的尼古丁盐的引入，电子烟在年轻人中的流行度呈指数级增长。虽然控制电子烟产品中的尼古丁水平很重要，但也应注意这些产品中存在的尼古丁形式，以解决人群中的尼古丁成瘾问题。