ABSTRACT

Previously, we found that yeast exhibits a strong growth defect with the combination of a lack of gene involved in structural modification of sphingolipids and repression of the phosphatidylserine synthase gene. Here we found that the double gene mutation causes reactive oxygen species-mediated cell growth defect, which is suppressed by deletion of LEM3 encoding the subunit of phospholipid flippase.

中文翻译：

---

ROS介导的合成生长缺陷是由于发芽酵母中的鞘脂和磷脂酰丝氨酸代谢受损所致。

摘要

以前，我们发现酵母菌表现出很强的生长缺陷，同时缺乏与鞘脂的结构修饰有关的基因和磷脂酰丝氨酸合酶基因的抑制。在这里，我们发现双基因突变会导致活性氧介导的细胞生长缺陷，这种缺陷可通过缺失编码磷脂翻转酶亚基的LEM3来抑制。