当前位置: X-MOL 学术Immun. Inflamm. Dis. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A role for the Sts phosphatases in negatively regulating IFNγ-mediated production of nitric oxide in monocytes.
Immunity, Inflammation and Disease ( IF 2.493 ) Pub Date : 2020-08-25 , DOI: 10.1002/iid3.336
Kaustubh Parashar 1 , Nicholas Carpino 1
Affiliation  

The atypical Sts phosphatases negatively regulate signaling pathways in diverse immune cell types, with two of their molecular targets being the related kinases Syk and Zap‐70. Mice lacking Sts expression (Sts−/−) are resistant to infection by the live vaccine strain (LVS) of Francisella tularensis. Although the mechanisms underlying the enhanced resistance of Sts−/− mice have not been definitively established, Sts−/− bone marrow‐derived monocytes (BMMs) demonstrate greater clearance of intracellular LVS following ex vivo infection, relative to wild type cells. To determine how the Sts proteins regulate monocyte bactericidal properties, we analyzed responses of infected cells.

中文翻译:

Sts 磷酸酶在负调节单核细胞中 IFNγ 介导的一氧化氮产生中的作用。

非典型 Sts 磷酸酶在不同免疫细胞类型中负向调节信号通路,它们的两个分子靶标是相关激酶 Syk 和 Zap-70。缺乏 Sts 表达 ( Sts -/- ) 的小鼠对土拉弗朗西斯菌( Francisella tularensis ) 活疫苗株 (LVS) 的感染具有抗性。尽管Sts -/-小鼠抵抗力增强的潜在机制尚未确定,但与野生型细胞相比,Sts -/-骨髓来源的单核细胞 (BMM) 在离体感染后表现出更大的细胞内 LVS 清除率。为了确定 Sts 蛋白如何调节单核细胞杀菌特性,我们分析了受感染细胞的反应。
更新日期:2020-08-25
down
wechat
bug