Human prorenin, representing the precursor of mature renin, has been discussed as a potential biomarker, e.g. in diagnosing primary hyperaldosteronism or diabetes‐induced nephropathy. Currently, only immunoassays are available for prorenin quantification. As prorenin's similarity to active renin impedes its accurate determination by immunoassay, mass spectrometry appears as an accurate alternative for differentiation of that protein.

中文翻译：

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混合免疫捕获液相色谱-质谱法测定人肾素原：利用D最佳设计的混合溶剂触发消解。

代表成熟肾素前体的人类肾素原作为一种潜在的生物标志物已被讨论，例如在诊断原发性醛固酮过多症或糖尿病引起的肾病中。当前，仅免疫测定可用于肾素原定量。由于前肾素与活性肾素的相似性阻碍了其通过免疫测定的准确测定，因此质谱法似乎是该蛋白质分化的准确替代方法。