Cancer Letters ( IF 9.7 ) Pub Date : 2020-08-26 , DOI: 10.1016/j.canlet.2020.08.013 Chengdi Wang 1 , Shuangyan Tan 2 , Jingwei Li 1 , Wen-Rong Liu 2 , Yong Peng 2 , Weimin Li 1
Lung cancer is the leading cause of malignancy-related incidence and mortality worldwide. Molecular mechanisms underlying tumorigenesis and development of lung cancer are still warranted to be elucidated. Previous studies have shown that non-coding RNAs are related to the tumorigenesis and progression of various cancers. However, the expression patterns and clinical implications of circRNAs in lung cancer remain obscure. CircRNAs are a special class of non-coding RNAs with stable covalently closed circular structures, high abundance and tissue/cell/development-specific expression patterns. Thus, circRNAs are a new frontier in lung cancer research. Therefore, in this review, we elucidated the biological function and mechanism of circRNAs, as well as the role of aberrant expressed circRNAs in proliferation, invasion, drug resistance and tumor microenvironment. Furthermore, we discussed that circRNAs may serve as potential clinical biomarkers for the diagnosis, prognosis and treatment of lung cancer.
中文翻译:
肺癌中的CircRNA-生物发生,功能和临床意义。
肺癌是全球范围内与恶性肿瘤相关的发病率和死亡率的主要原因。仍需要阐明肺癌的肿瘤发生和发展的分子机制。先前的研究表明,非编码RNA与多种癌症的发生和发展有关。然而,circRNA在肺癌中的表达模式和临床意义仍然不清楚。CircRNA是一类特殊的非编码RNA,具有稳定的共价闭合环状结构,高丰度和组织/细胞/发育特异性表达模式。因此,circRNAs是肺癌研究的一个新领域。因此,在这篇综述中,我们阐明了circRNA的生物学功能和机制,以及异常表达的circRNA在增殖,侵袭,耐药性和肿瘤微环境。此外,我们讨论了circRNAs可能作为肺癌的诊断,预后和治疗的潜在临床生物标志物。