Inflammatory responses play an extraordinary role in the pathogenesis of cerebrovascular and neurological disorders. Baicalin is one of the important flavonoids, which is extracted from Scutellaria baicalensis Georgi. Recently, numerous in vivo and in vitro studies have shown that baicalin has salutary effects for anti-inflammatory and immunomodulatory and has been demonstrated to exert beneficial therapeutic properties in cerebrovascular and neurological diseases. In this review, we aim to discuss that baicalin exerts anti-inflammatory effects through multiple pathways and targets, thus affecting the production of a variety of inflammatory cytokines and neuroprotective process of neurological diseases; furthermore, the related targets of the anti-inflammatory effects of baicalin were analyzed via using the tools of network pharmacology, to provide theoretical basis and innovative ideas for the future clinical application of baicalin.

炎症反应在脑血管和神经系统疾病的发病机制中发挥着非凡的作用。黄芩苷是重要的黄酮类化合物之一，从黄芩中提取。最近，大量的体内和体外研究表明，黄芩苷具有抗炎和免疫调节的有益作用，并已被证明在脑血管和神经系统疾病中发挥有益的治疗作用。本综述旨在探讨黄芩苷通过多种途径和靶点发挥抗炎作用，从而影响多种炎症细胞因子的产生和神经系统疾病的神经保护过程；此外，利用网络药理学工具分析了黄芩苷抗炎作用的相关靶点，