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Increased conceptual switching by dopaminergic treatment in patients with Parkinson's disease.
Brain and Cognition ( IF 2.5 ) Pub Date : 2020-08-25 , DOI: 10.1016/j.bandc.2020.105611
Hannes O Tiedt 1 , Felicitas Ehlen 2 , Fabian Klostermann 3
Affiliation  

Cognitive changes including reduced word production in verbal fluency (VF) tasks are frequently observed in Parkinson’s disease (PD) with ambiguous effects of dopaminergic medication on these symptoms. Here, we studied the impact of dopaminergic medication on specific cognitive components underlying VF task performance in 21 participants with PD on their regular medication and following dopamine withdrawal compared with healthy controls. We used temporal cluster analysis (TCA) to differentiate phases of VF output relating to fast automatic lexical activation (‘clusters’) and slower attention-demanding shifts (‘switches’). Dopaminergic medication led to increased switching and, in non-alternating VF tasks, to the formation of smaller and shorter word clusters. The number of switches was correlated with higher cognitive scores and showed an inverse relationship with VF error rates. Increased switching operations during VF task performance can be interpreted in view of nigrostriatal dopaminergic roles for balancing system state versus change propensities. The additional effect on word clustering suggests a modulation of semantic spreading activation mechanisms underlying lexical search, presumably involving non-nigrostriatal, e.g., mesocortical dopaminergic networks.



中文翻译:

多巴胺能治疗帕金森氏病患者的观念转换增加。

在帕金森氏病(PD)中经常观察到认知变化,包括言语流利(VF)任务中的单词生成减少,多巴胺能药物对这些症状产生模棱两可的效果。在这里,我们研究了多巴胺能药物对21名PD参与者常规饮食以及多巴胺戒断后与健康对照组相比VF任务表现基础的特定认知成分的影响。我们使用时间聚类分析(TCA)来区分与快速自动词法激活(“簇”)和较慢的注意力转移(“开关”)有关的VF输出阶段。多巴胺能药物导致增加的转换,并且在非替代性VF任务中导致形成越来越小的单词簇。开关的数量与较高的认知得分相关,并显示出与VF错误率成反比的关系。VF任务执行过程中增加的切换操作可以通过考虑黑纹状体多巴胺能平衡系统状态与变化倾向的作用来解释。对单词聚类的附加影响表明,对词法搜索基础上的语义扩展激活机制的调节可能与非黑质纹状体(例如中皮质多巴胺能网络)有关。

更新日期:2020-08-26
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