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Comprehensive biomedical applications of low temperature plasmas.
Archives of Biochemistry and Biophysics ( IF 3.9 ) Pub Date : 2020-08-26 , DOI: 10.1016/j.abb.2020.108560
Simone Duarte 1 , Beatriz H D Panariello 1
Affiliation  

The main component of plasma medicine is the use of low-temperature plasma (LTP) as a powerful tool for biomedical applications. LTP generates high reactivity at low temperatures and can be activated with noble gases with molecular mixtures or compressed air. LTP reactive species are quickly produced, and are a remarkably good source of reactive oxygen and nitrogen species including singlet oxygen (O2), ozone (O3), hydroxyl radicals (OH), nitrous oxide (NO), and nitrogen dioxide (NO2). Its low gas temperature and highly reactive non-equilibrium chemistry make it appropriate for the alteration of inorganic surfaces and delicate biological systems. Treatment of oral biofilm-related infections, treatment of wounds and skin diseases, assistance in cancer treatment, treatment of viruses’ infections (e.g. herpes simplex), and optimization of implants surfaces are included among the extensive plasma medicine applications. Each of these applications will be discussed in this review article.



中文翻译:

低温等离子体的综合生物医学应用。

等离子体医学的主要组成部分是使用低温等离子体 (LTP) 作为生物医学应用的强大工具。LTP 在低温下产生高反应性,可以用分子混合物或压缩空气的惰性气体激活。LTP 活性物质会迅速产生,并且是活性氧和氮物质的极佳来源,包括单线态氧 (O 2 )、臭氧 (O 3 )、羟基自由基 (OH)、一氧化二氮 (NO) 和二氧化氮 (NO 2个). 其低气体温度和高反应性非平衡化学使其适用于改变无机表面和脆弱的生物系统。等离子医学的广泛应用包括口腔生物膜相关感染的治疗、伤口和皮肤病的治疗、癌症治疗的辅助、病毒感染(例如单纯疱疹病毒)的治疗以及植入物表面的优化。这些应用程序中的每一个都将在这篇评论文章中进行讨论。

更新日期:2020-08-31
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