Purpose of Review

The purpose of this review is to evaluate and explain our current understanding of the clinical use of low-dose naltrexone in the treatment of chronic pain.

Recent Findings

Recent pre-clinical uses and clinical studies further elucidate the use of low-dose naltrexone in the treatment of chronic pain.

Summary

Low-dose naltrexone (LDN) has shown promise to reduce symptoms related to chronic pain conditions such as fibromyalgia, inflammatory bowel conditions, and multiple sclerosis. The mechanism of LDN appears to be modulation of neuro-inflammation, specifically, the modulation of the glial cells and release of inflammatory chemicals in the central nervous system. These effects appear to unique at low dosage compared to dosage for food and drug administration approved use for alcohol and opioid dependence. We review the evidence that LDN has shown more than promise and should be further investigated in clinical practice.

中文翻译：

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低剂量纳曲酮治疗慢性疼痛：更新和系统评价。

审查目的

这篇综述的目的是评估和解释我们目前对低剂量纳曲酮在治疗慢性疼痛中的临床应用的了解。

最近的发现

最近的临床前用途和临床研究进一步阐明了低剂量纳曲酮在慢性疼痛治疗中的用途。

概要

低剂量纳曲酮（LDN）已显示出有望减轻与慢性疼痛状况（如纤维肌痛，炎症性肠病和多发性硬化症）有关的症状的希望。LDN的机制似乎是神经炎症的调节，特别是神经胶质细胞的调节和中枢神经系统中炎症化学物质的释放。与批准用于酒精和阿片类药物依赖的食品和药物给药剂量相比，这些效果在低剂量时显得独特。我们回顾了LDN所显示出的远超预期的证据，应在临床实践中进行进一步研究。