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Advances in biomedical and pharmaceutical applications of protein-stabilized gold nanoclusters.
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2020-08-25 , DOI: 10.1039/d0tb01610a
Nesma El-Sayed 1 , Marc Schneider 2
Affiliation  

The interest in using gold nanoclusters (AuNCs) as imaging probes is growing, covering wide ranges of applications. The stabilization of AuNCs with protein ligands enhances their biomedical and pharmaceutical applications. This is due to the biocompatibility, water solubility and bioactivity of proteins. Different factors can control the optical properties of AuNCs such as protein size, amino acids content and conformational structure. Controlling the synthesis conditions can result in tuning the AuNCs excitation, emission, fluorescence intensity and physicochemical properties to fulfill different applications. NIR-emitting protein-stabilized AuNCs are promising as imaging agents for targeting and visualization of cancer in vitro and in vivo. They are promising to be included as an important part of multifunctional theranostic nanosystems, due to their potential dual functions as imaging and photosensitizing agent for photodynamic therapy. Additionally, the protein around AuNCs represents a rich environment of active functional groups that are susceptible for conjugation with various biomolecules. Protein–AuNCs can act as fluorescent probes for rapid and selective analysis of different analytes in solution, cells or biological fluids. In conclusion, the variability of protein–AuNC applications can advance research in different biomedical and pharmaceutical fields.

中文翻译:

蛋白质稳定的金纳米团簇在生物医学和药物学方面的应用进展。

使用金纳米团簇(AuNCs)作为成像探针的兴趣正在增长,涵盖了广泛的应用领域。用蛋白配体稳定AuNCs增强了其生物医学和制药应用。这是由于蛋白质的生物相容性,水溶性和生物活性。不同的因素可以控制AuNCs的光学特性,例如蛋白质大小,氨基酸含量和构象结构。控制合成条件可以调节AuNCs的激发,发射,荧光强度和理化性质,以满足不同的应用。NIR发射蛋白稳定AuNCs是有希望用作成像剂,用于定位和癌症可视化在体外体内。由于它们具有潜在的双重作用,可以用作光动力疗法的成像和光敏剂,因此有望被包含为多功能治疗法纳米系统的重要组成部分。另外,AuNCs周围的蛋白质代表了丰富的活性官能团环境,很容易与各种生物分子结合。Protein-AuNCs可以用作荧光探针,用于快速,选择性地分析溶液,细胞或生物流体中的不同分析物。总之,蛋白质-AuNC应用的可变性可以促进不同生物医学和制药领域的研究。
更新日期:2020-10-14
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