Nickel-based metal–organic frameworks (Ni-MOFs) have attracted increasing attention in non-enzymatic glucose sensing. However, the insufficient active Ni cation sites from a stacked MOF layer, the unclear Ni catalysis mechanism, and the severe liquid alkaline electrolyte remain challenging for practical applications. In this work, the sonication-induced longitudinal-expansion of Ni-MOFs increases the active nickel ion sites, which not only enhances the current response to glucose detection, but also shows the oxidation peak evolution of nickel ions with different sonication times, revealing the mechanism of different glucose detection channels. The Ni-MOF sonicated for 60 min (60 min Ni-MOF) displays enhanced Ni(III)/Ni(II) and more significant Ni(IV)/Ni(III) double nickel cation channels for catalyzing glucose into glucolactone compared to the 0 min Ni-MOF (without sonication), showing optimized glucose detection ability with a high sensitivity of 3297.10 μA mM⁻¹ cm⁻², a low detection limit of ∼8.97 μM (signal-to-noise = 3) and a wide linear response range from 10 to 400 μM from the cyclic voltammetry test as well as a high sensitivity of 3.03 μA mM⁻¹ cm⁻², a low detection limit of ∼1.16 μM (signal-to-noise = 3) and a wide linear response range from 10 to 2000 μM from the chronoamperometry test. More importantly, an all-solid-state glucose biosensor using a PVA/NaOH solid-state electrolyte and a disposable 60 min Ni-MOF working electrode is assembled for non-enzymatic sweat glucose detection.

中文翻译：

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纵向扩展的镍基金属有机骨架，具有增强的非酶汗葡萄糖生物传感器双镍阳离子催化反应通道。

镍基金属有机框架（Ni-MOF）在非酶促葡萄糖感测中引起了越来越多的关注。然而，来自堆叠的MOF层的活性Ni阳离子位点不足，不清楚的Ni催化机理以及严重的液态碱性电解质对于实际应用仍然具有挑战性。在这项工作中，超声诱导的Ni-MOFs的纵向扩展增加了活性镍离子的位点，这不仅增强了对葡萄糖检测的电流响应，而且还显示了不同超声处理时间下镍离子的氧化峰演变，揭示了葡萄糖检测通道的作用机理。超声处理60分钟（60分钟Ni-MOF）的Ni-MOF显示出增强的Ni（III）/ Ni（II）和更显着的Ni（IV）/ Ni（III）与0分钟Ni-MOF（无声处理）相比，双镍阳离子通道可将葡萄糖催化为葡萄糖内酯，显示了优化的葡萄糖检测能力，具有3297.10μAmM ^-1 cm ^-2的高灵敏度，低检测限为8.97 μM（信噪比= 3），循环伏安法测试的线性响应范围从10到400μM，以及3.03μAmM ^-1 cm ^-2的高灵敏度，通过计时电流法测试，检测限低至约1.16μM（信噪比= 3），线性响应范围从10至2000μM。更重要的是，组装了使用PVA / NaOH固态电解质和60分钟一次性Ni-MOF工作电极的全固态葡萄糖生物传感器，用于非酶促汗液葡萄糖检测。