As the most important bone-resorbing cells, osteoclasts play fundamental roles in bone remodeling and skeletal health. Much effort has been focused on identifying the regulators of osteoclast metabolism. Noncoding RNAs (ncRNAs) reportedly regulate osteoclast formation, differentiation, survival, and bone-resorbing activity to participate in bone physiology and pathology. The present review intends to provide a general framework for how ncRNAs and their targets regulate osteoclast differentiation and the important events of osteoclastogenesis they are involved in, including osteoclast precursor generation, early differentiation, mononuclear osteoclast fusion, and multinucleated osteoclast function and survival. This framework is beneficial for understanding bone biology and for identifying the potential biomarkers or therapeutic targets of bone diseases. The review also summarizes the results of in vivo experiments and classic experiment methods for osteoclast-related researches.

中文翻译：

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非编码 RNA 参与破骨细胞的分化。

作为最重要的骨吸收细胞，破骨细胞在骨重塑和骨骼健康中发挥着重要作用。许多努力都集中在确定破骨细胞代谢的调节因子上。据报道，非编码 RNA (ncRNA) 调节破骨细胞的形成、分化、存活和骨吸收活性，参与骨生理学和病理学。本综述旨在为 ncRNA 及其靶标如何调节破骨细胞分化及其参与的破骨细胞生成的重要事件提供一个总体框架，包括破骨细胞前体生成、早期分化、单核破骨细胞融合以及多核破骨细胞功能和存活。该框架有利于理解骨生物学和识别骨疾病的潜在生物标志物或治疗靶点。综述还总结了破骨细胞相关研究的体内实验结果和经典实验方法。