Stress ( IF 2.3 ) Pub Date : 2020-09-04 , DOI: 10.1080/10253890.2020.1813711 Jason T Carbone 1
Abstract
This study explored the associations between specific profiles of biological dysregulation and mental health outcomes in a national, community sample of healthy adults in the United States. A latent class analysis of data from the Midlife Development in the United States study (n = 1,757) was conducted to determine classes of biological dysregulation. Multinomial logistic regressions of class membership were employed to determine associations with measures related to depression, including whether or not individuals had sought treatment, Center for Epidemiological Studies Depression Scale, and both the generalized distress and anhedonia subscales of the Mood and Anxiety Symptoms Questionnaire. Four classes of dysregulation emerged: baseline/low dysregulation, metabolic and inflammatory dysregulation, parasympathetic dysregulation, and SAM pathway dysregulation. Individuals who met the criteria for depression measures were more likely to be in the metabolic and immune dysregulation and parasympathetic dysregulation groups as compared to the baseline group. The results suggest that mental health outcomes, such as depression, are differentially associated with specific profiles of biological dysregulation. A more nuanced approach to profiles of dysregulation could better inform treatment decisions.
- Lay summary
Higher levels of allostatic load, which represents the cumulative wear and tear of exposure to stress, are associated with increased rates of depression and anhedonia. Specifically, parasympathetic dysregulation and immunometabolic dysregulation are associated with negative mental health outcomes
中文翻译:
平衡负荷与心理健康:生理失调的潜在类别分析
摘要
本研究在美国健康成年人的全国社区样本中探讨了生物失调的特定特征与心理健康结果之间的关联。美国中年发展研究(n = 1,757) 被用来确定生物失调的类别。班级成员的多项逻辑回归被用来确定与抑郁症相关措施的关联,包括个人是否寻求治疗、流行病学研究中心抑郁量表,以及情绪和焦虑症状问卷的广义痛苦和快感缺乏子量表。出现了四类失调:基线/低失调、代谢和炎症失调、副交感神经失调和 SAM 通路失调。与基线组相比,符合抑郁测量标准的个体更有可能属于代谢和免疫失调以及副交感神经失调组。结果表明,心理健康结果,例如抑郁症,与生物失调的特定特征不同。对失调情况采取更细致入微的方法可以更好地为治疗决策提供信息。
- 奠定总结
较高水平的静态负荷(代表暴露于压力的累积磨损和撕裂)与抑郁和快感缺乏的发生率增加有关。具体而言,副交感神经失调和免疫代谢失调与负面心理健康结果相关