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Quantitative investigation on the effects of ice crystal size on freeze-drying: The primary drying step
Drying Technology ( IF 3.3 ) Pub Date : 2020-08-24 , DOI: 10.1080/07373937.2020.1806865
Chun Luo 1 , Zhiqiang Liu 1 , Sha Mi 1 , Longquan Li 1
Affiliation  

Abstract

The size of ice crystals formed in the freezing process has a significant impact on the subsequent primary drying process. However, the effects have not been fully understood. The purpose of this study was to quantitatively investigate the effects of ice crystal size on water vapor concentration, temperature, and primary drying time. A mathematical model considering the effects of ice crystals size was proposed, and it was solved by Comsol Multiphysics. Results show that there is less water vapor in the products with larger ice crystals. Temperature is found to decrease initially, and larger ice crystals lead to a higher temperature in the dried zone while the lower temperature in the frozen zone. The primary drying process proceeds faster when the ice crystal size is large, and the decrement of primary drying time gets smaller when further increasing the size of ice crystals. This work could provide help for the optimization of freeze-drying.



中文翻译:

冰晶尺寸对冷冻干燥影响的定量研究:初级干燥步骤

摘要

冷冻过程中形成的冰晶的大小对后续的初级干燥过程产生重大影响。但是,尚未完全了解其影响。本研究的目的是定量研究冰晶尺寸对水蒸气浓度、温度和初级干燥时间的影响。提出了一个考虑冰晶尺寸影响的数学模型,并由Comsol Multiphysics求解。结果表明,具有较大冰晶的产品中的水蒸气较少。发现温度最初下降,较大的冰晶导致干燥区温度较高,而冷冻区温度较低。冰晶尺寸越大,一次干燥过程进行得越快,进一步增大冰晶尺寸,一次干燥时间的减少量越小。

更新日期:2020-08-24
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