A micellar electrokinetic capillary chromatography (MEKC) method with ultraviolet visible (UV) detection was used for the determination of 1,7‐naphthalenediol, 2,3‐naphthalenediol, 1,5‐naphthalenediol, and 2,7‐naphthalenediol in cosmetics. The current method for their determination in various cosmetics is high‐performance liquid chromatography (HPLC). Separation conditions affecting the MEKC method were optimized as 20 mM Na₂B₄O₇–50mM SDS, pH 9.8, with 22 kV applied voltage and UV detection at 230 nm. Under optimal conditions, electrophoretic analysis was completed in less than 6 min, with limit of detection (LOD) of 0.070–0.19 μg/mL and limit of quantitation (LOQ) of 0.23–0.63 μg/mL. A good linear relationship (r² > 0.99) was obtained at the range of 0.75–20 μg/mL. Recoveries for the four naphthalenediols in lotion, loose powder, and sun cream are between 91.2–107.2% with relative standard deviation (RSD) less than 4.04%. The method has been successfully applied to the determination of the four naphthalenediols in different kinds of cosmetics. A comparison with HPLC‐UV method was also carried out according to the National Standards of the People's Republic of China. The results obtained by MEKC and HPLC methods are comparable, but the proposed MEKC method can help us obtain a much shorter detection time and low cost.

中文翻译：

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胶束电动毛细管色谱法的发展，用于测定化妆品中的四种萘二醇并与HPLC方法进行比较。

胶束电动毛细管色谱法（MEKC）和紫外可见（UV）检测用于化妆品中1,7-萘二醇，2,3-萘二醇，1,5-萘二醇和2,7-萘二醇的测定。目前在各种化妆品中测定其含量的方法是高效液相色谱（HPLC）。影响MEKC方法的分离条件优化为20 mM Na ₂ B ₄ O ₇ –50mM SDS，pH 9.8，施加电压22 kV，在230 nm处进行UV检测。在最佳条件下，电泳分析在不到6分钟的时间内完成，检测限（LOD）为0.070-0.19μg/ mL，定量限（LOQ）为0.23-0.63μg/ mL。良好的线性关系（r ²> 0.99）的浓度范围为0.75–20μg/ mL。洗剂，散粉和防晒霜中四种萘二醇的回收率在91.2-107.2％之间，相对标准偏差（RSD）小于4.04％。该方法已成功应用于不同化妆品中四种萘二醇的测定。还根据中华人民共和国国家标准与HPLC-UV方法进行了比较。通过MEKC和HPLC方法获得的结果是可比的，但是提出的MEKC方法可以帮助我们获得更短的检测时间和更低的成本。