Fertilization failure (FF) is a complex reproductive disorder characterized by the failure of pronuclei formation during fertilization. In addition to some cases caused by iatrogenic problems and known genetic factors, there are still many unexplained aspects of FF. Here, we aimed to assess the clinical and genetic characteristics of two families experiencing primary infertility with FF.

中文翻译：

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PLCZ1基因中的新突变与人类受精率低或失败有关。

受精失败（FF）是一种复杂的生殖疾病，其特征是受精过程中前核形成失败。除了某些由医源性问题和已知遗传因素引起的病例外，FF仍有许多无法解释的方面。在这里，我们旨在评估两个患有FF的原发性不育症的家庭的临床和遗传特征。