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In vivo biocompatibility evaluation of Zn-0.05Mg-(0, 0.5, 1wt%)Ag implants in New Zealand rabbits
Biomaterials Advances ( IF 7.9 ) Pub Date : 2020-08-25 , DOI: 10.1016/j.msec.2020.111435
Chi Xiao , Xin Ying Shi , Wei Ting Yu , Xiao Wei Wei , Liang Liang Cheng , Xing Qiu , Bo Rui Li , De Chao Fan , Jun Lei Li , Xiu Zhi Zhang , De Wei Zhao

Bio-absorbable Zn alloys have been attractive replacements for the traditionally permanent implants due to their reasonable mechanical strength and elongation, degradation rate, and biocompatibility. The hybridization addition of Mg and Ag elements could greatly improve the mechanical properties and antibacterial ability of Zn, respectively. In the present paper, in vivo biocompatibility for the Zn-0.05Mg-(0, 0.5, 1 wt%) Ag implants in New Zealand rabbit was qualitatively evaluated during the implantation periods of 4, 12, and 24 weeks. The blood serum biochemical parameters and in vivo integrity of the implants in the live rabbits were monitored by using clinical chemistry analyzing and X-ray radiographic imaging techniques during the implantation process, respectively. There is no great difference in the serum biochemical indicator between the implanted rabbits and the control group. Especially the levels of serum Zn and serum Mg normalize after implantation of 24 weeks. The interfacial adherence between the implants and newly formed bones, and the histopathological morphology of heart, liver, and kidney were observed morphologically under the microscope. The new bones formed and grew surrounding the implants after 12 weeks' post-operation, which were well joined with the original cortical bones after post-implantation of 24 weeks. The heart, liver and kidney were not negatively influenced as evidenced from the serum biochemical indicators and morphologies of the tissues. Zn-0.05Mg-(0, 0.5, 1 wt%) Ag alloys are proved to be in vivo biocompatible and potential candidates for the biodegradable medical implants.



中文翻译:

新西兰兔体内Zn-0.05Mg-(0,0.5,1wt%)Ag植入物的体内生物相容性评估

由于具有合理的机械强度和延伸率,降解率和生物相容性,可生物吸收的锌合金已成为传统永久植入物的有吸引力的替代品。Mg和Ag元素的杂化添加可以分别极大地提高Zn的机械性能和抗菌能力。在本文中,定性评估了在4、12和24周的植入期中,新西兰兔体内Zn-0.05Mg-(0、0.5、1 wt%)Ag植入物的体内生物相容性。血清生化指标及体内通过在植入过程中分别使用临床化学分析和X射线射线照相成像技术监测活兔中植入物的完整性。植入的兔子和对照组之间的血清生化指标没有很大差异。植入后24周,尤其是血清Zn和Mg的水平恢复正常。在显微镜下观察植入物与新形成的骨头之间的界面粘附性,以及心脏,肝脏和肾脏的组织病理学形态。术后12周,新的骨头在植入物周围形成并生长,并在植入后24周与原始皮质骨头良好地结合在一起。心,从血清生化指标和组织形态可以看出,肝脏和肾脏没有受到负面影响。Zn-0.05Mg-(0,0.5,1 wt%)Ag合金被证明是可生物降解的医用植入物的体内生物相容性和潜在候选物。

更新日期:2020-09-08
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