Abstract In current study, we developed a highly stable electrocatalyst via integration of AgBr particles into the polymeric structure of polythiophene through the doping process that formed a highly active catalysis for rapid/repeatable oxidation of glucose via electrochemical approaches for real time detection of blood sugar. The developed platform consisted of highly crystalline polythiophene-AgBr (PT-AgBr) that exhibited a well-ordered hybrid cubic/nanorode morphology with positive zeta potential value and electrophoretic mobility of 16.7 mV/0.000129 cm2/Vs, respectively. Moreover, examination of the developed platform via CV and amperometric techniques revealed the superior performance/accuracy of the fabricated biosensor and showed limit of detection (LOD) / sensitivity of 370 nM/756 µA mM−1 cm−2 and 310 nM/10.4 µA mM−1 cm−2 for CV and amperometric techniques, respectively. More importantly, PT-AgBr can detect the glucose through a real-time approach with accuracy more than 99% at day 1 and more than 90% till day 14, while presence of interfering compounds within the biological/non-biological samples has negligible effect on the sensing performance of developed biosensor. Evaluation of real samples furtherly confirmed the superior role of the PT-AgBr that recovered about 97.1% of the glucose within the human blood plasma containing plenty of annoying species.

中文翻译：

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聚噻吩溴化银纳米结构作为超灵敏非酶电化学葡萄糖生物传感器

摘要 在目前的研究中，我们开发了一种高度稳定的电催化剂，通过掺杂过程将 AgBr 颗粒整合到聚噻吩的聚合物结构中，通过电化学方法实时检测血糖，形成一种高活性的葡萄糖快速/重复氧化催化剂。开发的平台由高度结晶的聚噻吩-AgBr (PT-AgBr) 组成，其表现出有序的混合立方/纳米电极形态，具有正 zeta 电位值和电泳迁移率分别为 16.7 mV/0.000129 cm2/Vs。此外，通过 CV 和电流分析技术对开发的平台进行检查，揭示了制造的生物传感器的卓越性能/准确性，并显示检测限 (LOD)/灵敏度为 370 nM/756 µA mM-1 cm-2 和 310 nM/10。对于 CV 和电流分析技术，分别为 4 µA mM-1 cm-2。更重要的是，PT-AgBr 可以通过实时方法检测葡萄糖，在第 1 天准确度超过 99%，到第 14 天准确度超过 90%，而生物/非生物样品中存在干扰化合物的影响可以忽略不计关于开发的生物传感器的传感性能。对真实样品的评估进一步证实了 PT-AgBr 的优越作用，它在含有大量烦人物质的人血浆中回收了约 97.1% 的葡萄糖。而生物/非生物样品中干扰化合物的存在对开发的生物传感器的传感性能的影响可以忽略不计。对真实样品的评估进一步证实了 PT-AgBr 的优越作用，它在含有大量烦人物质的人血浆中回收了约 97.1% 的葡萄糖。而生物/非生物样品中干扰化合物的存在对开发的生物传感器的传感性能的影响可以忽略不计。对真实样品的评估进一步证实了 PT-AgBr 的优越作用，它在含有大量恼人物种的人血浆中回收了约 97.1% 的葡萄糖。