Abstract (E)-1-((((1H-benzo[d]imidazol-2-yl)methyl)imino)methyl)naphthalen-2-ol, ligand was synthesized by condensation of (1H-benzo[d]imidazol-2-yl) methanamine, with 2-hydroxynaphthaldehyde. The ligand and the metal complexes were characterized by various spectroscopic techniques. Interpretation of spectra confirmed that the ligand adopted either a neutral tridentate or a monobasic tridentate mode, bonded to the metal ions through the nitrogen atom of the heterocyclic benzimidazole, azomethine nitrogen atom and deprotonated phenolic oxygen atom forming either a square planer geometry. X-ray powder diffraction analysis of complexes indicated that the complexes were crystalline in nature with triclinic structures. The antibacterial and the antifungal activities of the ligand and its complexes were examined against Escherichia coli, Bacillus subtilis and Aspergillus niger by well- diffusion method. The results showed that Cd (II) complex exhibits the highest antifungal and antibacterial activities among the tested complexes. The in vitro antitumor activityies of the different complexes were tested and the results revealed an important cytotoxicity of cadmium complex against MCF-7, Hep G2 and HCT 116 cell. Iron complex showed also a strong toxicity towards Hep G2 and HCT cell whereas moderate activity against MCF-7. The bioassay study of different complexes against mosquito larvae demonstrated strong activity of zirconium complex with 0.172 values of LC50.

中文翻译：

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源自席夫碱 2-氨基甲基苯并咪唑、2-羟基萘醛的锆 (IV)、镉 (II) 和铁 (III) 配合物的设计、合成、表征及其生物活性评价

摘要 (E)-1-((((1H-benzo[d]imidazol-2-yl)methyl)imino)methyl)naphthalen-2-ol，配体由(1H-benzo[d]imidazol- 2-基）甲胺，与 2-羟基萘醛。配体和金属配合物通过各种光谱技术表征。光谱解释证实，配体采用中性三齿或一元三齿模式，通过杂环苯并咪唑的氮原子、偶氮甲碱氮原子和去质子化酚氧原子与金属离子键合，形成方形平面几何形状。配合物的X-射线粉末衍射分析表明配合物是具有三斜结构的晶体。检查了配体及其复合物对大肠杆菌的抗菌和抗真菌活性，枯草芽孢杆菌和黑曲霉通过井扩散法。结果表明，Cd (II) 复合物在测试的复合物中表现出最高的抗真菌和抗菌活性。测试了不同复合物的体外抗肿瘤活性，结果表明镉复合物对 MCF-7、Hep G2 和 HCT 116 细胞具有重要的细胞毒性。铁复合物对 Hep G2 和 HCT 细胞也表现出强烈的毒性，而对 MCF-7 则表现出中等活性。不同复合物对蚊子幼虫的生物测定研究表明，锆复合物具有很强的活性，LC50 值为 0.172。测试了不同复合物的体外抗肿瘤活性，结果表明镉复合物对 MCF-7、Hep G2 和 HCT 116 细胞具有重要的细胞毒性。铁复合物对 Hep G2 和 HCT 细胞也表现出强烈的毒性，而对 MCF-7 则表现出中等活性。不同复合物对蚊子幼虫的生物测定研究表明，锆复合物具有很强的活性，LC50 值为 0.172。测试了不同复合物的体外抗肿瘤活性，结果表明镉复合物对 MCF-7、Hep G2 和 HCT 116 细胞具有重要的细胞毒性。铁复合物对 Hep G2 和 HCT 细胞也表现出强烈的毒性，而对 MCF-7 则表现出中等活性。不同复合物对蚊子幼虫的生物测定研究表明，锆复合物具有很强的活性，LC50 值为 0.172。