Purpose: Dexamethasone has been widely used to treat acute inflammatory diseases and endotoxic shocks in animal models. Meloxicam is one of the most commonly used anti-inflammatory agents in avian species. However, little is known about the effects of dexamethasone and meloxicam on lipopolysaccharide (LPS)-induced acute inflammatory response in birds. In the present study, LPS-challenged broiler chickens were used to investigate the comparative protective effects of meloxicam and dexamethasone on LPS-induced acute inflammatory responses.
Methods: Lipopolysaccharide (LPS)-induced acute lung injury (ALI) histopathological scores, selected serum acute phase reactants, inflammatory mediators, and gangliosides were evaluated in broiler chickens inoculated with E. coli LPS and simultaneously treated with two doses of meloxicam (0.5 and 2 mg/kg BW) and dexamethasone (2 and 4 mg/kg BW).
Results: LPS-induced ALI scores were not significantly different between the meloxicam-treated, dexamethasone-treated, and untreated positive control groups at 4 hours after LPS inoculation. Interleukin-6 concentrations were also statistically the same among the positive control, dexamethasone-treated, and meloxicam-treated groups at 3 and 12 hours after LPS inoculation. However, these anti-inflammatory drugs reduced adenosine deaminase, ceruloplasmin, lipid-bound sialic acid, protein-bound sialic acid, and total sialic acid in LPS-inoculated broiler chickens at 12, 24, and 48 hours after LPS inoculation in a drug- and dose-dependent manner. Ovotransferrin concentrations were not significantly different between positive control and treatment groups at 12 hours after LPS inoculation. However, twenty-four hours after LPS inoculation, all the treated groups, except the one treated with 0.5 mg/kg meloxicam, showed significantly lower concentrations of ovotransferrin as compared with the positive control group.
Conclusion: Our results showed that dexamethasone was more effective than meloxicam in inhibiting the LPS-induced response in broiler chickens by diminishing the serum levels of adenosine deaminase, ceruloplasmin, and gangliosides.

Keywords: lipopolysaccharide, meloxicam, dexamethasone, interleukin-6, acute phase proteins, chickens


中文翻译：

---

地塞米松和美洛昔康对肉鸡大肠杆菌脂多糖诱导的急性炎症反应幅度的比较影响。

目的：地塞米松已广泛用于治疗动物模型中的急性炎症性疾病和内毒素性休克。美洛昔康是禽类中最常用的抗炎药之一。然而，关于地塞米松和美洛昔康对脂多糖（LPS）诱导的鸟类急性炎症反应的影响知之甚少。在本研究中，LPS 攻击的肉鸡用于研究美洛昔康和地塞米松对 LPS 诱导的急性炎症反应的比较保护作用。
方法：在接种大肠杆菌的肉鸡中评估脂多糖 (LPS) 诱导的急性肺损伤 (ALI) 组织病理学评分、选定的血清急性期反应物、炎症介质和神经节苷脂。LPS，同时用两剂美洛昔康（0.5 和 2 mg/kg BW）和地塞米松（2 和 4 mg/kg BW）治疗。
结果：在 LPS 接种后 4 小时，LPS 诱导的 ALI 评分在美洛昔康治疗组、地塞米松治疗组和未治疗阳性对照组之间没有显着差异。在 LPS 接种后 3 和 12 小时，阳性对照组、地塞米松治疗组和美洛昔康治疗组之间的白细胞介素 6 浓度在统计学上也相同。然而，这些抗炎药在 LPS 接种后 12、24 和 48 小时降低了 LPS 接种肉鸡的腺苷脱氨酶、铜蓝蛋白、脂质结合唾液酸、蛋白质结合唾液酸和总唾液酸。和剂量依赖的方式。在 LPS 接种后 12 小时，阳性对照组和治疗组之间的卵转铁蛋白浓度没有显着差异。然而，在 LPS 接种后 24 小时，所有治疗组，
结论：我们的研究结果表明，地塞米松通过降低血清腺苷脱氨酶、铜蓝蛋白和神经节苷脂的水平，在抑制肉鸡 LPS 诱导的反应方面比美洛昔康更有效。

关键词：脂多糖，美洛昔康，地塞米松，白细胞介素6，急性期蛋白，鸡