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Multifunctional nano-enabled delivery systems in Alzheimer's disease management.
Biomaterials Science ( IF 6.6 ) Pub Date : 2020-08-24 , DOI: 10.1039/d0bm00756k
Chengyuan Qian 1 , Chengyi Yuan , Changhong Li , Hao Liu , Xiaohui Wang
Affiliation  

Alzheimer's disease (AD) is the most common neurodegenerative disorder that leads to cognitive and behavioral impairment. Unfortunately, both effective diagnosis and treatment for AD remain elusive, probably owing to the complicated and uncertain etiology of the disease. To date, a number of hypotheses have been proposed that may explain AD pathogenesis, including the amyloid cascade hypothesis, the tau hypothesis, the cholinergic hypothesis, the metal ion hypothesis, the oxidative stress hypothesis and so on. Thus, the development of multifunctional compounds capable of concurrently targeting multiple pathogenic factors of AD has been suggested as an effective solution to combat this disease. Nano-enabled delivery systems (NDS) have promising potential to achieve multifunctional diagnostics/therapeutics against various targets of AD simultaneously due to the unique advantages of nanocarriers, such as easy multifunctionalization on surfaces, high surface-to-volume ratio with large payloads, and potential ability to cross the blood–brain barrier (BBB), making them capable of overcoming the limitations of traditional drug candidates. This review focuses on the recent developments of multifunctional NDS in AD management, including multitherapeutics, multimodal imaging-guided diagnostics, and theranostics. The multifunctionalization strategies, working mechanisms, and in vivo activities of the representative examples are highlighted. Finally, the opportunities and challenges of multifunctional NDS for future research are also discussed.

中文翻译:

阿尔茨海默氏病管理中的多功能纳米递送系统。

阿尔茨海默氏病(AD)是导致认知和行为受损的最常见神经退行性疾病。不幸的是,可能由于该病的病因复杂且不确定,AD的有效诊断和治疗仍然难以捉摸。迄今为止,已经提出了许多可以解释AD发病机理的假说,包括淀粉样蛋白级联假说,tau假说,胆碱能假说,金属离子假说,氧化应激假说等等。因此,已经提出开发能够同时靶向AD的多种致病因素的多功能化合物作为对抗该疾病的有效解决方案。纳米载体的递送系统(NDS)由于纳米载体的独特优势(如表面上的多功能化,具有高有效负载的高表面积/体积比)和纳米载体的独特优势,有望同时针对AD的各种目标实现多功能诊断/治疗。穿越血脑屏障(BBB)的潜在能力,使其有能力克服传统候选药物的局限性。这篇综述着重于AD治疗中多功能NDS的最新发展,包括多疗法,多模式成像指导的诊断和治疗学。多功能化策略,工作机制和 以及穿越血脑屏障(BBB)的潜在能力,使其有能力克服传统候选药物的局限性。这篇综述着重于AD治疗中多功能NDS的最新发展,包括多疗法,多模式成像指导的诊断和治疗学。多功能化策略,工作机制和 以及穿越血脑屏障(BBB)的潜在能力,使其有能力克服传统候选药物的局限性。这篇综述着重于AD治疗中多功能NDS的最新发展,包括多疗法,多模式成像指导的诊断和治疗学。多功能化策略,工作机制和突出了体内活性的代表性实例。最后,还讨论了多功能NDS在未来研究中的机遇和挑战。
更新日期:2020-10-13
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