KIR+NKG2A + Eomes+ CD8+ T cells, which are preferentially found with a T_EMRA (CD45RA + CCR7−) phenotype while having the capacity to rapidly produce IFN-γ in response to innate stimulation (IL-12 and IL-18), have been demonstrated to exist in human cord blood and the adult blood circulation. This highly responsive T-cell type was termed NK-like CD8+ T cells due to their capability to act in an innate immune fashion in mice similar to NK cells. However, KIR+NKG2A + CD8+ T cells that are Eomes− represent a small proportion of unconventional T cells that have not been described until now.

中文翻译：

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KIR + NKG2A + Eomes− NK 样 CD8+ T 细胞的特征及其随年龄增长在健康个体中的下降

KIR+NKG2A + Eomes+ CD8+ T 细胞，优先发现具有 T _EMRA (CD45RA + CCR7-) 表型，同时具有响应先天刺激（IL-12 和 IL-18）快速产生 IFN-γ 的能力，具有已被证明存在于人类脐带血和成人血液循环中。这种高度反应性的 T 细胞类型被称为 NK 样 CD8+ T 细胞，因为它们能够在与 NK 细胞相似的小鼠中以先天免疫方式发挥作用。然而，作为 Eomes- 的 KIR+NKG2A + CD8+ T 细胞代表了一小部分迄今为止尚未描述的非常规 T 细胞。