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Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation.
ChemPlusChem ( IF 3.4 ) Pub Date : 2020-08-23 , DOI: 10.1002/cplu.202000502
Masato Kobayashi 1, 2 , Mei Harada 3 , Hideo Takakura 3 , Kanta Ando 3 , Yuto Goto 3 , Takao Tsuneda 1, 4 , Mikako Ogawa 3 , Tetsuya Taketsugu 1, 2
Affiliation  

Invited for this month's cover are the collaborating groups of Dr. Masato Kobayashi and Prof. Mikako Ogawa, both from Hokkaido University, Sapporo, Japan. The cover picture shows the photochemical reaction process of the near‐infrared (NIR) photoimmunotherapy dye IR700, and subsequent cancer cell death. A computational study predicted that ligand dissociation, which is known to initiate cancer cell death, proceeds by the hydrolysis of the IR700 radical anion, rather than as a direct result of NIR irradiation. This mechanism has also been supported by experimental work. Read the full text of the Communication at 10.1002/cplu.202000338.

中文翻译:

酞菁硅光免疫疗法染料的近红外光反应机理的理论和实验研究:自由基阴离子产生的光致水解。

来自日本札幌北海道大学的Masato Kobayashi博士和Mikako Ogawa教授的协作小组邀请了本月的封面。封面图片显示了近红外(NIR)光免疫疗法染料IR700的光化学反应过程,以及随后的癌细胞死亡。一项计算研究预测,已知配体离解是引发癌细胞死亡的原因,它是通过IR700自由基阴离子的水解而不是NIR辐射的直接结果而进行的。该机制也得到了实验工作的支持。阅读通讯全文,网址为10.1002 / cplu.202000338。
更新日期:2020-09-01
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