502

A systematic review and meta‐analysis of the effect of Vitamin D‐fortified food on glycemic indices

Maryam Emadzadeh, Reza Sahebi, Hamed Khedmatgozar, Ramin Sadeghi, Mahsa Farjami, Payam Sharifan, Yalda Ravanshad, Gordon A. Ferns and Majid Ghayour‐Mobarhan

Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta‐analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published up to September 2018 and that compared the effect of Vitamin D‐fortified food versus regular diet in relation to glycemic control. Of the 4,379 studies originally found, 11 articles remained to be assessed for meta‐analysis. Vitamin D fortification was associated with a significant improvement in fasting serum glucose (mean difference [MD]: −2.772; 95% confidence interval [CI]: −5.435 to −0.109) and fasting serum insulin (MD: −2.937; 95% CI: −4.695 to −1.178) in patients with Type 2 diabetes mellitus. A diet with food enriched with Vitamin D was associated with a significant improvement in homeostatic model assessment of insulin resistance (MD: −1.608; 95% CI: −3.138 to −0.079) but was not associated with a significant reduction in hemoglobin A1C (MD: 0.034; 95% CI: −0.655 to 0.069). This meta‐analysis indicates that Vitamin D fortification improves indices of glycemic control. Hence, food fortified with Vitamin D may be of potential therapeutic value in diabetic patients, as an adjuvant therapy.

502

维生素D强化食品对血糖指数的影响的系统评价和荟萃分析

Maryam Emadzadeh，Reza Sahebi，Hamed Khedmatgozar，Ramin Sadeghi，Mahsa Farjami，Payam Sharifan，Yalda Ravanshad，Gordon A.Ferns和Majid Ghayour-Mobarhan

一些报告表明维生素D可以改善糖尿病患者的血糖指数。这项系统和荟萃分析的目的是评估维生素D强化对血糖控制指标的影响。搜索了六个数据库（PubMed / Medline，ISI Web of Knowledge，Cochrane图书馆，Science Direct，Scopus和Google Scholar），以研究截至2018年9月的随机对照试验，并比较了维生素D强化食品与定期饮食与血糖控制有关。最初发现的4379篇研究中，仍有11篇文章需要进行荟萃分析。维生素D强化与空腹血清葡萄糖（平均差异[MD]：-2.772； 95％置信区间[CI]：-5.435至-0.109）和空腹血清胰岛素（MD：-2.937； 95％CI）显着改善：−4.695至-1。178）2型糖尿病患者。饮食中富含维生素D的食物与胰岛素抵抗的稳态模型评估显着改善有关（MD：-1.608； 95％CI：-3.138至-0.079），但与血红蛋白A1C的显着降低没有关联（MD ：0.034； 95％CI：-0.655至0.069）。这项荟萃分析表明，维他命D强化可以改善血糖控制指标。因此，以维生素D强化的食物作为辅助疗法可能对糖尿病患者具有潜在的治疗价值。034; 95％CI：-0.655至0.069）。这项荟萃分析表明，维他命D强化可以改善血糖控制指标。因此，以维生素D强化的食物作为辅助疗法可能对糖尿病患者具有潜在的治疗价值。034; 95％CI：-0.655至0.069）。这项荟萃分析表明，维他命D强化可以改善血糖控制指标。因此，以维生素D强化的食物作为辅助疗法可能对糖尿病患者具有潜在的治疗价值。