This article reviews work over the past three decades that is related to the contribution of the pacemaker current, I_f, to basal and autonomically regulated spontaneous rate in the sinoatrial node. It also addresses how the actions of the pacemaker current relate to those of Ca homeostasis with respect to basal and autonomically regulated rhythm. In this regard, it explores the relative contributions of Ca-sensitive and Ca-insensitive isoforms of adenylyl cyclase to sinoatrial node automaticity. The latter studies include previously unpublished work making use of mice in which both the type 1 and type 8 Ca-sensitive adenylyl cyclase isoforms were knocked out. These studies indicate that the pacemaker current and the L-type Ca current are distinctly influenced by Ca-sensitive and insensitive adenylyl cyclase isoforms.

本文回顾了过去三年中与起搏器电流 I _{f的贡献相关的工作}, 到窦房结的基础和自主调节的自发率。它还解决了起搏器电流的作用如何与 Ca 稳态有关基础和自主调节的节律。在这方面，它探讨了腺苷酸环化酶的 Ca 敏感和 Ca 不敏感异构体对窦房结自律性的相对贡献。后者的研究包括以前未发表的使用小鼠的研究，其中 1 型和 8 型 Ca 敏感腺苷酸环化酶同种型均被敲除。这些研究表明起搏器电流和 L 型 Ca 电流明显受 Ca 敏感和不敏感的腺苷酸环化酶异构体的影响。