Abstract

Despite great efforts and advancement in the treatment of cancer, tumor recurrence and metastasis remain significant challenges and demand novel therapy strategies. Recently, advances in biomaterials and drug delivery systems have facilitated the development of the local therapy of cancer, among which electrospun nanofibrous scaffolds show great promise owing to their porous structure, relatively large surface area, high drug loading capacity, similarity with the native extracellular matrix, and possibility of the combination of various therapies. Here, we review this rapidly developing field of electrospun nanofibrous scaffolds as a drug delivery system for cancer local therapy, in particular addressing stimuli-responsive drug release, as well as its combination with stem cell and immune therapy. Challenges and future perspectives are also discussed.

Graphic Abstract

中文翻译：

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功能性电纺纤维用于癌症的局部治疗

摘要

尽管在癌症的治疗上付出了巨大的努力和进步，但是肿瘤的复发和转移仍然是重大的挑战，并需要新颖的治疗策略。近年来，生物材料和药物输送系统的发展促进了癌症局部疗法的发展，其中电纺纳米纤维支架由于其多孔结构，相对较大的表面积，高载药量以及与天然细胞外基质的相似性而具有广阔的前景。 ，以及各种疗法相结合的可能性。在这里，我们回顾了电纺纳米纤维支架这一迅速发展的领域，它是一种用于癌症局部治疗的药物输送系统，特别是解决了刺激反应性药物释放及其与干细胞和免疫疗法的结合。

图形摘要