One of the main features of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease is the amyloidogenic behavior of disease-specific proteins including amyloid β, tau, α-synuclein, and mutant Huntingtin which participate in the formation, accumulation, and deposition of toxic misfolded aggregates. Consequently, these proteins not only associated with the progress of their respective neurodegenerative pathologies but also qualify as disease-specific biomarkers. The aim of using natural polyphenols is to target amyloid-dependent proteopathies by decreasing free radical damage and inhibiting and dissolving amyloid fibrils. We explore the effectiveness of the polyphenols epigallocatechin-3-gallate, oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid β, tau, and α-synuclein and mitigate other pathological features for Alzheimer’s disease and Parkinson’s disease. The analysis was carried from in vitro and cell line studies to animal models and clinical trials. This Review describes the use of phytochemical compounds as prophylactic agents for Alzheimer’s disease, Parkinson’s disease, and other proteopathies.

中文翻译：

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天然多酚对蛋白质聚集毒性的潜在作用：体外，体内和临床研究。

神经退行性疾病（例如阿尔茨海默氏病和帕金森氏病）的主要特征之一是疾病特异性蛋白质（包括淀粉样蛋白β，tau，α-突触核蛋白和突变的亨廷顿蛋白）的淀粉样蛋白生成行为，它们参与了毒性错折叠的形成，积累和沉积。聚集体。因此，这些蛋白质不仅与它们各自的神经退行性病变的进展有关，而且还可以作为疾病特异性的生物标志物。使用天然多酚的目的是通过减少自由基损伤并抑制和溶解淀粉样蛋白原纤维来靶向淀粉样蛋白依赖性蛋白病。我们探索了多酚表没食子儿茶素-3-没食子酸酯，橄榄苦苷糖苷配基和槲皮素对它们抑制淀粉样蛋白β，tau，和α-突触核蛋白并减轻阿尔茨海默氏病和帕金森氏病的其他病理特征。分析来自体外和细胞系研究，以动物模型和临床试验。该评价描述了使用植物化学化合物作为阿尔茨海默氏病，帕金森氏病和其他蛋白病的预防剂。