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Nonleaching antimicrobial poly(vinyl alcohol)/polyhexamethylene guanidine hydrochloride hydrogels reinforced by hydrogen bond
Polymers for Advanced Technologies ( IF 3.4 ) Pub Date : 2020-08-21 , DOI: 10.1002/pat.5048
Wuling Gong 1 , Dafu Wei 1 , Shaotian Zhang 1 , Yachao Jiang 1 , Jingyun Ye 1 , Anna Zheng 1 , Yong Guan 1
Affiliation  

Antimicrobial poly(vinyl alcohol) (PVA) hydrogels attracted much attentions in the last decade. In this work, a novel antimicrobial PVA hydrogel was prepared through compounding PVA with polyhexamethylene guanidine hydrochloride (PHMG) and freezing‐thawing method. These composite hydrogels behaved above 99.9% of antimicrobial rates against both Escherichia coli and Staphylococcus aureus even at 0.003 wt% of PHMG, and the nonleaching characteristic of PHMG as well as long‐acting antimicrobial activities. The PVA/0.100 wt% PHMG hydrogel had 120% higher tensile strength than pure PVA hydrogel, and its water vapor transmission rate was 4530 ± 245 g/m2/d, which was at an optimal range for injured skin (279‐5138 g/m2/d). This work provides a simple approach to develop nonleaching antimicrobial PVA hydrogels with extremely few PHMG for wound dressing and other potential applications in biomedical field.

中文翻译:

氢键增强的非浸出抗菌聚乙烯醇/聚六亚甲基胍盐酸盐水凝胶

在过去的十年中,抗菌聚乙烯醇(PVA)水凝胶引起了很多关注。在这项工作中,通过将PVA与聚六亚甲基胍盐酸盐(PHMG)混合并冷冻融化的方法制备了一种新型的PVA抗菌水凝胶。这些复合水凝胶即使在PHMG为0.003 wt%时,对大肠杆菌金黄色葡萄球菌的抗菌率仍高于99.9%,并具有PHMG的非浸出特性和长效抗菌活性。PVA / 0.100 wt%PHMG水凝胶的拉伸强度比纯PVA水凝胶高120%,其水蒸气透过率是4530±245 g / m 2 / d,这是受伤皮肤的最佳范围(279-5138 g /米2/ d)。这项工作提供了一种简单的方法来开发具有极少PHMG的非浸出抗菌PVA水凝胶,用于伤口敷料和生物医学领域中的其他潜在应用。
更新日期:2020-08-21
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