Combining structural (sMRI) and functional magnetic resonance imaging (fMRI) data in schizophrenia patients with and without auditory hallucinations (9 SZ_AVH, 12 SZ_nAVH), 18 patients with bipolar disorder, and 22 healthy controls, we examined whether cortical thinning was associated with abnormal activity in functional brain networks associated with auditory hallucinations. Language-task fMRI data were combined with mean cortical thickness values from 148 brain regions in a constrained principal component analysis (CPCA) to identify brain structure-function associations predictable from group differences. Two components emerged from the multimodal analysis. The "AVH component" highlighted an association of frontotemporal and cingulate thinning with altered brain activity characteristic of hallucinations among patients with AVH. In contrast, the "Bipolar component" distinguished bipolar patients from healthy controls and linked increased activity in the language network with cortical thinning in the left occipital-temporal lobe. Our findings add to a body of evidence of the biological underpinnings of hallucinations and illustrate a method for multimodal data analysis of structure-function associations in psychiatric illness.

中文翻译：

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精神分裂症中的幻觉特异性结构功能关联

结合有和没有幻听的精神分裂症患者（9 SZ_AVH，12 SZ_nAVH）、18 名双相情感障碍患者和 22 名健康对照的结构（sMRI）和功能磁共振成像（fMRI）数据，我们检查了皮质变薄是否与异常相关与幻听相关的功能性大脑网络中的活动。语言任务 fMRI 数据与来自 148 个大脑区域的平均皮质厚度值在约束主成分分析 (CPCA) 中相结合，以确定可从组差异中预测的大脑结构-功能关联。多模态分析中出现了两个组成部分。“AVH 成分”强调了额颞叶和扣带回变薄与 AVH 患者幻觉的大脑活动特征改变之间的关联。相比之下，“双极成分”将双极患者与健康对照区分开来，并将语言网络中的活动增加与左侧枕颞叶的皮质变薄联系起来。我们的研究结果增加了幻觉生物学基础的大量证据，并说明了一种对精神疾病结构-功能关联进行多模态数据分析的方法。