Abstract In this study, wound dressings consisting of dexpanthenol (Dex)-loaded electrospun nanofibers were fabricated using polyvinyl alcohol (PVA)/sodium alginate (SA), and chitosan as the core and the shell, respectively. Considering the remarkable properties of chitosan, it was used as a shell against drug release and to improve the thermal stability, and tensile strength of the scaffold. By comparing the thermogravimetric, and tensile strength results of nanofibers with and without shell, it was revealed that the presence of chitosan in the shell side could improve the thermal stability and increased the tensile strength by about three times. The isotherm models of dexpanthenol release from the PVA/SA/Dex-CS scaffold was best described by the Langmuir model. Besides, Fourier transform infrared, scanning electron microscopy, and X-ray diffraction techniques were performed to characterize nanofibers. Furthermore, an in vivo investigation of a wound dressing with dexpanthenol showed better healing compared to the wound dressings without dexpanthenol.

中文翻译：

---

用于伤口愈合的右泛醇缓释纳米纤维的制备、表征和体内评价

摘要 在本研究中，以聚乙烯醇（PVA）/海藻酸钠（SA）和壳聚糖分别为核和壳，制备了由负载右泛醇（Dex）的电纺纳米纤维组成的伤口敷料。考虑到壳聚糖的显着特性，它被用作防止药物释放的外壳并提高支架的热稳定性和拉伸强度。通过比较有壳和无壳纳米纤维的热重和拉伸强度结果，发现壳侧壳聚糖的存在可以提高热稳定性并将拉伸强度提高约三倍。Langmuir 模型最好地描述了从 PVA/SA/Dex-CS 支架中释放右泛醇的等温线模型。此外，傅里叶变换红外、扫描电子显微镜、和 X 射线衍射技术被用来表征纳米纤维。此外，对含有右泛醇的伤口敷料的体内研究表明，与不含右泛醇的伤口敷料相比，愈合效果更好。