Abstract Anti-vitamin K (AVK) compounds are highly potent anticoagulants which are particularly effective for controlling rodent species populations. AVKs have been the most widely used chemical rodenticide option employed since the 1950s for the control of rodents infesting stored commodities and storage facilities, and also in a wide range of other scenarios. However, reports of AVK resistance in wild rodent populations are becoming increasingly common. This could potentially lead to a substantial reduction in AVK efficacy resulting in an impaired ability to manage rodent infestations in the future. The current state of knowledge regarding AVK resistance mechanisms in common pest species is still incomplete. This review draws together reported incidences of AVK resistance in the literature and the underlying mechanisms suspected of conferring resistance for the three main pest rodent species Rattus norvegicus, Rattus rattus and Mus musculus. The purpose of this review is to compare and contrast the underlying resistance mechanisms in these species and demonstrate how this should influence programs for monitoring and avoiding the development of AVK resistance in target rodent species.

中文翻译：

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啮齿动物害虫的抗凝血灭鼠剂和抗性发展——综合综述

摘要 抗维生素 K (AVK) 化合物是高效的抗凝血剂，对控制啮齿动物种群特别有效。自 1950 年代以来，AVK 一直是使用最广泛的化学杀鼠剂选项，用于控制侵扰储存商品和储存设施的啮齿动物，以及其他各种情况。然而，关于野生啮齿动物群体中 AVK 抗性的报道正变得越来越普遍。这可能会导致 AVK 功效的显着降低，从而导致未来管理啮齿动物感染的能力受损。目前关于常见害虫物种 AVK 抗性机制的知识状态仍然不完整。本综述汇总了文献中报道的 AVK 抗性发生率以及可能对三种主要害虫啮齿动物物种褐家鼠、大鼠和家鼠产生抗性的潜在机制。本综述的目的是比较和对比这些物种的潜在抗性机制，并展示这将如何影响监测和避免目标啮齿动物物种 AVK 抗性发展的计划。