The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.

帕金森氏病（PD）的治疗受到血脑屏障（BBB）的阻碍。因此，迫切需要开发能够穿透BBB以有效治疗PD的新型纳米平台。在本研究中，我们利用含有脑靶向配体乳铁蛋白（Lf）并负载Pa药苷（Pae）的黑磷纳米片（BP）来获得Lf-BP-Pae。通过有效的光热效应，这些Lf-BP-Pae颗粒能够穿过BBB并有针对性地有效治疗PD。重要的是，这种基于BP的纳米平台能够实现令人满意的生物相容性和生物安全性，同时具有出色的抗帕金森病功效，使其成为临床应用的理想选择。