The mechanical properties of injectable and thermo-responsive ABC triblock copolymer hydrogels are enhanced by the electrostatic attraction between oppositely charged moieties introduced in the mid-blocks. The triblock copolymers are composed of biodegradable poly(ε-caprolactone) (PCL), hydrophilic cationic or anionic mid-block, and temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) with quadruple hydrogen bonding units. PCL blocks and PNIPAM blocks form separate micellar cores, and the mid-blocks make a bridge between the cores. The dynamic nature and thermo-responsiveness of the PNIPAM block primarily endow the temperature- and shear-responsiveness to the hydrogel, and therefore make the hydrogel injectable and self-healable. In particular, the electrostatic attraction introduced in the mid-blocks results in the enhanced mechanical properties of the hydrogels. The dual-responsive hydrogel with the improved moduli will aid in designing soft materials in the field of biological and biomedical applications.

中文翻译：

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基于静电缔合的具有改进机械性能的可注射水凝胶

可注射和热响应 ABC 三嵌段共聚物水凝胶的机械性能通过中间嵌段中引入的带相反电荷的部分之间的静电吸引力得到增强。三嵌段共聚物由可生物降解的聚（ε-己内酯）（PCL）、亲水性阳离子或阴离子中间嵌段和具有四重氢键单元的温度响应性聚（N-异丙基丙烯酰胺）（PNIPAM）组成。PCL 块和 PNIPAM 块形成单独的胶束核，中间块在核之间架起一座桥梁。PNIPAM 块的动态特性和热响应性主要赋予水凝胶温度和剪切响应性，因此使水凝胶可注射和自愈。特别是，在中间块中引入的静电吸引力导致水凝胶的机械性能增强。具有改进模量的双响应水凝胶将有助于设计生物和生物医学应用领域的软材料。