Genetic susceptibility, dietary cholesterol intake and plasma cholesterol levels in a Chinese population.,Journal of Lipid Research

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Genetic susceptibility, dietary cholesterol intake and plasma cholesterol levels in a Chinese population.
Journal of Lipid Research ( IF 6.5 ) Pub Date : 2020-08-12 , DOI: 10.1194/jlr.ra120001009
Shaofeng Huo ₁ , Liang Sun ₁ , Geng Zong ₁ , Boyu Song ₁ , He Zheng ₁ , Qianlu Jin ₁ , Huaixing Li ₂ , Xu Lin _{3,

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Affiliation

Accompanied with nutrition transition, non-HDL-cholesterol (HDL-C) levels of Asian countries increased rapidly, which has caused the global epicenter of non-optimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical to underline major genetic and dietary determinants. In the current study of 2,330 Chinese individuals, genetic risk scores (GRSs) were calculated for total cholesterol (TC; GRS_TC, 57 SNPs), LDL-cholesterol (LDL-C; GRS_LDL-C, 45 SNPs) and HDL-C (GRS_HDL-C, 65 SNPs) based on SNPs from the Global Lipid Genetics Consortium study. Cholesterol intake was estimated by a 74-item food frequency questionnaire. Associations of dietary cholesterol intake with plasma TC and LDL-C strengthened across quartiles of the GRS_TC (effect sizes = -0.29, 0.34, 2.45 and 6.47; P_interaction = 0.002) and GRS_LDL-C (effect sizes = -1.35, 0.17, 5.45 and 6.07; P_interaction = 0.001), respectively. Similar interactions on non-HDL-C were observed between dietary cholesterol and GRS_TC (P_interaction = 0.001) and GRS_LDL-C (P_interaction = 0.004). The adverse effects of GRS_TC on TC (effect sizes across dietary cholesterol quartiles: 0.51, 0.82, 1.21 and 1.31; P_interaction = 0.023) and GRS_LDL-C on LDL-C (effect sizes across dietary cholesterol quartiles: 0.66, 0.52, 1.12 and 1.56; P_interaction = 0.020) were more profound in those having higher cholesterol intake compared to those with lower intake. Our findings suggest significant interactions between genetic susceptibility and dietary cholesterol intake on plasma cholesterol profiles in a Chinese population.

更新日期：2020-08-24

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