Osteoarthritis (OA) is a disease that leads to the damage of subchondral bone. To treat OA, patients can have surgery to implant biomaterials into the damaged area. In this research, biomaterials of 3D porous scaffolds were fabricated by the use of air microbubbles for subchondral bone formation proposed for OA surgery. Microbubbles were generated in a polyvinyl alcohol solution at various air flow rates of 20 (F20), 100 (F100), 200 (F200), and 300 (F300) cc min −1 . Molecular organization, structure, and morphology of the scaffolds were characterized and observed by Fourier transform infrared spectroscopy, a differential scanning calorimeter, and a scanning electron microscope, respectively. Physical and mechanical properties based on swelling behavior and compressive strength of the scaffolds were also evaluated. Biological performance by means of osteoblast proliferation, protein synthesis, and alkaline phosphatase activity of the scaffolds were studied. The scaffold...

中文翻译：

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用于骨关节炎手术软骨下骨形成的聚乙烯醇微泡多孔支架的构建。

骨关节炎（OA）是一种导致软骨下骨损伤的疾病。为了治疗 OA，患者可以通过手术将生物材料植入受损区域。在这项研究中，3D 多孔支架的生物材料是通过使用空气微泡制造的，用于 OA 手术的软骨下骨形成。在聚乙烯醇溶液中以20 (F20)、100 (F100)、200 (F200)和300 (F300) cc min -1 的各种空气流速产生微泡。分别通过傅里叶变换红外光谱、差示扫描量热仪和扫描电子显微镜对支架的分子组织、结构和形态进行表征和观察。还评估了基于支架的溶胀行为和压缩强度的物理和机械性能。通过成骨细胞增殖、蛋白质合成和支架的碱性磷酸酶活性研究了生物学性能。脚手架...