Depression is one of the most common forms of mental illness and also a leading cause of disability worldwide. Developing novel antidepressant targets beyond the monoaminergic systems is now popular and necessary. LIM kinases, including LIM domain kinase 1 and 2 (LIMK1/2), play a key role in actin and microtubule dynamics through phosphorylating cofilin. Since depression is associated with atrophy of neurons and reduced connectivity, here we speculate that LIMK1/2 may play a role in the pathogenesis of depression.

中文翻译：

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mPFC 中的 LIMK1/2 在小鼠慢性应激诱导的抑郁样效应中起作用。

抑郁症是最常见的精神疾病形式之一，也是世界范围内导致残疾的主要原因。开发单胺能系统以外的新型抗抑郁药靶点现在很流行也很有必要。LIM 激酶，包括 LIM 域激酶 1 和 2 (LIMK1/2)，通过磷酸化 cofilin 在肌动蛋白和微管动力学中发挥关键作用。由于抑郁症与神经元萎缩和连接性降低有关，因此我们推测 LIMK1/2 可能在抑郁症的发病机制中发挥作用。