A new cryo-EM structure of mitochondrial complex I reveals ordered water molecules that connect key elements of the proton-translocating machinery. Analysis of the ubiquinone-binding site of complex I offers insights into the mechanism of catalytic turnover and the regulation of this essential metabolic enzyme.

中文翻译：

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线粒体复合体I中质子泵送的水路。

线粒体复合体I的一种新的低温电磁结构揭示了有序的水分子，这些水分子连接了质子转运机器的关键元件。复合物I的泛醌结合位点的分析提供了对催化周转机理和这种必需的代谢酶的调控的见解。