Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study.,Experimental Gerontology

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Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study.
Experimental Gerontology ( IF 3.9 ) Pub Date : 2020-08-22 , DOI: 10.1016/j.exger.2020.111064
Yoshikazu Matsuda ₁ , Hisao Haniu ₂ , Tamotsu Tsukahara ₃ , Takeshi Uemura ₄ , Toshio Inoue ₁ , Ken-Ichi Sako ₁ , Jun Kojima ₅ , Tatsuro Mori ₆ , Kazusaburou Sato ₇

Affiliation

Background and objectives

Porcine liver decomposition product (PLDP) contains neurofunctional phospholipids. We previously reported that PLDP enhances cognitive function in healthy adult humans, based on clinical evaluations using Hasegawa's Dementia Scale-Revised. In this study, we evaluated the effect of PLDP on memory indicators of the Wechsler Memory Scale-Revised (WMS-R), an internationally recognized battery for memory assessment.

Methods

We conducted a double-blind parallel-group placebo-controlled trial to evaluate the effect of PLDP on memory. Fifty-eight participants competed the trial: 28 participants were in the PLDP group and 30 participants were in the placebo group. Each group was administered PLDP (4 capsules) or a placebo (4 capsules) for 4 continuous weeks. WMS-R was administered before and 4 weeks after PLDP or placebo intake. The data were also subdivided by age for participants under 40 years (N = 15 in PLDP; N = 15 in placebo) and over 40 years (N = 13 in PLDP, N = 15 in placebo). Changes in Verbal Memory, Visual Memory, Attention/Concentration, and Delayed Recall were analyzed.

Results

No significant differences were found in any memory indicators between the PLDP group and the placebo group in pooled participants and in participants under 40 years of age. However, for participants over 40 years of age, PLDP administration resulted in a significant enhancement than placebo administration in Delayed Recall (14.1 ± 7.1 points vs. 7.1 ± 6.8 points) (P < 0.05), Visual Recall I (20.1 ± 23.1 percentile vs 1.9 ± 22.8 percentile) (P < 0.05), and Visual Recall II (24.2 ± 25.8 percentile vs 6.7 ± 19.0 percentile) (P < 0.05), respectively. The composition ratio of men to women in each group was imbalanced but no significant difference existed between the two groups.

Limitations

A modest sample size, single-center design, and a fairly short follow-up period.

Conclusion

PLDP enhanced Visual Memory and Delayed Recall in healthy adults over 40 years of age but not in healthy adults under 40 years of age. Therefore, PLDP may represent a promising nutraceutical that could improve cognitive function in healthy adults over 40 years of age. Further studies are required to evaluate if long term PLDP administration can prevent or delay cognitive dysfunction in healthy adults over 40 years of age.

中文翻译：

口服猪肝分解产物4周可增强40岁以上健康成年人的视觉记忆力并延缓其回忆：一项随机，双盲，安慰剂对照的研究。

背景和目标

猪肝分解产物（PLDP）包含神经功能磷脂。我们先前曾报道，基于使用长谷川氏痴呆量表修订版的临床评估，PLDP增强了健康成年人的认知功能。在这项研究中，我们评估了PLDP对Wechsler记忆量表修订版（WMS-R）的记忆指标的影响，WMS-R是国际公认的记忆评估电池。

方法

我们进行了一项双盲平行组安慰剂对照试验，以评估PLDP对记忆的影响。58名参与者参加了该试验：PLDP组28名参与者，安慰剂组30名参与者。每组连续4周接受PLDP（4粒胶囊）或安慰剂（4粒胶囊）。WMS-R在PLDP或安慰剂摄入之前和之后4周服用。对于年龄在40岁以下（PLDP中N = 15；在安慰剂中N = 15）和40岁以上（PLDP中N = 13，在安慰剂中N = 15）的参与者，数据也按年龄细分。分析了言语记忆，视觉记忆，注意力/注意力和延迟回忆的变化。

结果

在汇集参与者和40岁以下参与者中，PLDP组和安慰剂组之间的任何记忆指标均无显着差异。然而，对于40岁以上的参与者，在延迟召回（14.1±7.1分与7.1±6.8分）（P <0.05），视觉召回I（20.1±23.1％与1.9±22.8个百分点）（P <0.05）和Visual Recall II（24.2±25.8个百分点vs 6.7±19.0个百分点）（P <0.05）。每组的男女组成比例不平衡，但两组之间没有显着差异。