The iodine-initiated cationic skeletal Wagner–Meerwein rearrangement in tetrahydro-3a,6-epoxyisoindol-1-ones has been studied. It was shown that by the action of iodine acetate in acetic anhydride the reaction proceeds regio- and stereoselectively with the formation of 5-iodo-4,6-epoxycyclopenta[c]pyridin-4-yl acetates. The proposed reagent provides better yields of rearrangement products than those described in the literature.

中文翻译：

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乙酸碘作为3a，6-环氧异吲哚中Wagner-Meerwein重排的温和选择剂

已经研究了碘在四氢3a，6-环氧异吲哚-1-酮中引发的阳离子骨架Wagner-Meerwein重排。结果表明，通过乙酸碘在乙酸酐中的作用，该反应在区域和立体选择性上进行，形成了乙酸5-碘-4,6-环氧环戊[ c ]吡啶-4-基。所提出的试剂提供了比文献所述更好的重排产物产率。