T helper 17 (Th17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). However, the role of Th17 cells in psoriasis has not been clarified completely. Th17-derived proinflammatory cytokines including IL-17A, IL-17F, IL-21, IL-22, and IL-26 have a critical role in the pathogenesis of these disorders. In this review, we introduced the signaling and transcriptional regulation of Th17 cells. And then, we demonstrate the immunopathology role of Th17 cells and functions of the related cytokines in the psoriasis to get a better understanding of the inflammatory mechanisms mediated by Th17 cells in this disease.

T 辅助 17 (Th17) 细胞参与了许多自身免疫性和炎症性疾病的发病机制，如银屑病、多发性硬化症 (MS)、类风湿性关节炎 (RA) 和炎症性肠病 (IBD)。然而，Th17细胞在银屑病中的作用尚未完全阐明。Th17 衍生的促炎细胞因子，包括 IL-17A、IL-17F、IL-21、IL-22 和 IL-26，在这些疾病的发病机制中具有关键作用。在这篇综述中，我们介绍了 Th17 细胞的信号传导和转录调控。然后，我们证明了 Th17 细胞在银屑病中的免疫病理学作用和相关细胞因子的功能，以更好地了解 Th17 细胞在该疾病中介导的炎症机制。