Indole-3-acetic acid (IA, urine-like toxin) coexisting with atorvastatin (AT) was adsorbed by spherical carbonaceous adsorbents (SCs). The relationship between the competitive adsorption kinetics and the mesoporous structures was investigated. The pore structures of the four SCs were analyzed using the Hg and gas adsorption methods. SC adsorption tests were performed using the dissolution test with the paddle method with an SC sample in distilled water containing IA and/or AT at 37.0 °C. The amounts of IA and AT adsorbed on SCs in single- and binary-drug administration tests were measured based on the ultraviolet-visible spectra using classical least squares analysis. Rate constants for the drug adsorption of IA and AT by SCs (kIA and kAT, respectively) were suppressed by the effect of coexisting drugs. The suppression of IA adsorption by the coexisting drug was dependent on the pore structure of the SCs. kIA and kAT against the SCs were competitively inhibited by coexisting drugs. Fig. a Graphical abstract Graphical abstract

中文翻译：

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介孔特性对体外慢性肾功能衰竭治疗模型中尿毒症样毒素和阿托伐他汀在球形碳吸附剂上的竞争吸附动力学的影响

与阿托伐他汀 (AT) 共存的吲哚-3-乙酸 (IA，尿样毒素) 被球形碳吸附剂 (SC) 吸附。研究了竞争吸附动力学与介孔结构之间的关系。使用 Hg 和气体吸附方法分析了四种 SCs 的孔结构。SC 吸附测试使用桨法溶解测试进行，SC 样品在含有 IA 和/或 AT 的蒸馏水中在 37.0 °C 下进行。在单药和二药给药试验中，吸附在 SCs 上的 IA 和 AT 的量是使用经典最小二乘分析基于紫外-可见光谱测量的。SCs（分别为kIA和kAT）对IA和AT的药物吸附速率常数受到共存药物的影响。共存药物对 IA 吸附的抑制取决于 SCs 的孔结构。针对 SCs 的 kIA 和 kAT 被共存药物竞争性抑制。图 a 图形摘要 图形摘要